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Why you should choose 4-Butylresorcinol?

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Why you should choose 4-Butylresorcinol?

2025-01-15

What is 4-Butylresorcinol?

4-Butyl resorcinol is a derivative of resorcinol, which has certain cytotoxicity and whitening effect, and is a prohibited whitening ingredient. However, 4-Butyl resorcinol is usually non-toxic and harmless to skin after structural change. However, some people have skin intolerance to 4-butyl resorcinol, so when using it, tolerance should be gradually established, otherwise the face will appear red, swelling and other allergic phenomena. In addition, the action principle of 4-butyl resorcinol is to inhibit the activity of tyrosinase before the formation of melanin, and promote the secretion of melanin to decrease. When melanin is formed, 4-butyl resorcinol will inhibit the transfer of melanin to keratinocytes, thus achieving whitening effect. In addition, 4-butyl resorcinol is a small molecule compound, which is easy to penetrate into the basal layer of the skin and has a fast action rate. Adhering to the use of 4-butylresorcinol for a long time will also play a certain role in weakening the aging spots, and at the same time can also weaken the acne marks caused by melanosis.

Mechanism action of 4-Butylresorcinol

  • Tyrosinase plays a crucial role in melanin production because it controls the rate of melanin deposition.
  • 4-n-butylresorcinol has an inhibitory effect on melanin production by directly inhibiting the activity of tyrosinase and B16 black-speed tumor cells inhibiting the synthesis of tyrosinase without causing any cytotoxicity.
  • In some in vitro studies, 4-n-butylresorcinol was shown to inhibit melanin production, as well as tyrosinase activity and TRP-1.

4-butylresorcinol whitening agent.png

Benefits of 4-Butylresorcinol

  • Strong inhibitor of tyrosinase and peroxidase
  • Effective skin whitening agent and normal skin toner
  • An effective whitening agent for pigmentation of the skin
  • Effective against chloasma (exposed hyperpigmented skin in the sun)
  • It has a strong protective effect on DNA damage induced by H2O2.
  • Proven to have an anti-glycation effect

Why you should choose 4-Butylresorcinol

First, we need to know why there is resorcinol.

Lipofuscin is one of the more difficult to deal with in melanin. In general, hydroquinone is used in medical beauty.

Hydroquinone is a very effective whitening agent. The whitening mechanism completely inhibits the activity of tyrosinase and prevents the formation of melanin, and the effect is very remarkable.

However, its side effects are equally obvious, and the benefits are much more harmful than the benefits of whitening.

  • It is highly oxidizable in the air, and it must be used when adding it to cosmetics.
  • can cause redness of the skin;
  • If the concentration exceeds 5%, it will cause sensitization, and there are clinical examples of leukoplakia. Currently, the US Food and Drug Administration stipulates that hydroquinone products with a concentration greater than 4% are medical grade and are not allowed to be marketed.

Chemists and pharmacists have modified the potent drug hydroquinone to get 4-hydroxyphenyl-beta-D-glucopyranoside, which is what we often hear about as “arbutin”. The difference between hydroquinone is that arbutin has a small tail – glycoside than hydroquinone. It is a pity that the whitening effect is greatly reduced.

 Dosage and usage of 4-Butylresorcinol

The recommended dosage is 0.5%-5%. Although there are studies in Korea that have a certain effect on 0.1% cream, India has researched 0.3% cream but the market is mainly 0.5%-5%. It is more common, and the Japanese formula is still unclear, but POLA has been used. And the results and sales are quite impressive.

As mentioned above, 4-Butylresorcinol can be used in creams, but it is insoluble in water. Others such as lotions, creams, and gels are also available. Both POLA and Eucerin have 4-Butylresorcinol products.