ε-Polylysine
ε-Polylysine is a linear polymer of lysine. It is produced by streptomyces fermentation and has a broad-spectrum antibacterial effect.ε-Polylysine is polymerized by 25-30 lysine groups, which is relatively stable to pH and heat.Its antibacterial effect is related to the degree of polymerization and the environment.The molecular weight of polylysine is between 3600-4300 which has the best antibacterial activity.
FAs a secondary metabolite, ε-Polylysine was first discovered from the soil bacterium Streptomyces albulus, which is still used in its commercial production. Later, more producers of ε-Polylysine were identified from the family of Streptomycetaceae, including the genera Streptomyces and Kitasatospora,and ergot fungi.ε-Polylysine is synthesized by a cell-membrane-bound nonribosomal peptide synthetase (NRPS)-like enzyme named ε-PL synthetase (Pls).
ε-Polylysine is a small cationic isopeptide made from the essential amino acid L-lysine. It exhibits antimicrobial activity against a wide spectrum of bacteria, yeast, and fungi and is heat stable and active in different food matrices.
ε-Polylysine (ε-PL) is a natural, broad-spectrum antimicrobial agent that inhibits bacteria (e.g., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) and fungi (e.g., Candida albicans, Aspergillus brasiliensis) commonly found in cosmetics, ensuring product quality and safety.
ε-Polylysine (ε-PL) has bactericidal activity against Malassezia furfur (causing dandruff) and Propionibacterium acnes (causing acne), making it useful in hair treatments and anti-acne cosmetics.
ε-PL enhances the antimicrobial efficacy of existing cosmetic preservatives (e.g., octanediol, grapefruit seed extract) and can reduce the required amounts of traditional preservatives (e.g., alkanediols), making cosmetics alcohol-free, paraben-free, and phenoxyethanol-free. As a cationic polymer, ε-PL reduces hair dryness and static electricity, alleviating damage caused by bleaching and improving hair manageability
Key Technical Parameters
|
Appearance |
Light yellow powder |
|
condition |
Powder, no lumps, no odor |
|
ε-polylysine content (dry basis), w/% |
≥94 |
|
Loss on Drying, w/% |
≤5.0 |
|
Arsenic(calculated As AS2)/(mg/kg) |
≤0.5 |
|
Lead(Pb)/(mg/kg) |
≤1.0 |
|
Ash content, w/% |
≤2.0 |
|
Total Colony Count(cfu/g) |
≤50000 |
|
Escherichia Coli(cfu/g) |
≤30 |
Applications
● Anti-acne effect
● Anti-aging effect
● Antimicrobial effect
● Moisturizing effect
Advantages
● Natural source
● Mild and low irritation
● Specific Bactericidal Effects:
● Antimicrobial and Preservative Effects
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