Tioxolone
Tioxolone,the compound's solubility varies across different solvents; it is soluble in 95% ethanol, benzene, diethyl ether, isopropanol, propylene glycol, and toluene, but insoluble in water. These properties make Tioxolone suitable for various formulations, particularly in topical applications.
Thioxolone has astringent characteristics.Astringent ingredients in cosmetic products shrink or tighten the skin and reduce oiliness. This results in a temporary reduction in the appearance of pores and an overall smoother, firmer skin texture. Astringents can also help to remove excess dirt and oil from the skin, making it feel clean and refreshed. They are commonly found in toners, cleansers, and other skincare products targeted toward oily or acne-prone skin.
Key Technical Parameters
| Appearance | Off white to yellow crystalline powder |
| Solubility | Practically insoluble in water,slight soluble in ethnol |
| Melting Point | 158.0℃~160.0℃ |
| Identifications | Forward Reaction |
| Consisten with RS. | |
| Chloride | ≤0.1% |
| Related Substance | Resorcinol ≤0.1% |
| Impurities A≤0.2% | |
| Unspecified Max.Impurities≤0.1% | |
| Total≤0.5% | |
| Residual Organic Solvent | Ethanol≤0.5% |
| Loss on Drying | ≤0.5% |
| Sulphated Ash | ≤0.1% |
| Heavy metals | ≤20ppm |
| Assay | ≥98.5% |
Tioxolone is a potent inhibitor of carbonic anhydrase I, a metalloenzyme involved in various physiological processes. Its inhibitory action is characterized by a Ki value of 91 nM, indicating high potency. Unlike traditional carbonic anhydrase inhibitors, Tioxolone lacks sulfonamide, sulfamate, or hydroxamate groups, suggesting a unique mechanism of action. It is proposed to act as a prodrug, undergoing cleavage via a carbonic anhydrase II zinc-hydroxide mechanism to form 4-mercaptobenzene-1,3-diol, which binds to the enzyme's active site.
Tioxolone has been extensively used in dermatological treatments, particularly for conditions such as psoriasis vulgaris and acne. Its antiseborrheic, antibacterial, and anti-mycotic properties make it a valuable component in topical formulations. Additionally, Tioxolone is incorporated into cosmetics like hair shampoos and skin cleansers for its oil-regulating and antibacterial benefits. The compound's ability to induce apoptosis in certain pathogens, such as Leishmania tropica, further underscores its potential in treating skin infections.
Applications
● Tighten skin effect
● Anti-acne effect
● Anti-bacterial effect
● Anti-inflammatory effect
Advantages
● Smoothen skin
● Resist wrinkles
● Firm skin
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