Alpha Ketoglutarate
Alpha-ketoglutarate (α-KG) is a precursor of glutamine and plays a pivotal role in multiple metabolic processes. In skin care, it is a powerful anti-wrinkle and skincare ingredient working as a natural moisturizing factor (NMF), barrier function enhancer, collagen booster, Hair growth stimulator, muscle toner, and wound healer. Its detoxification property against free radicals shows its ability to prevent the deterioration of collagen and elastin.
α-Ketoglutarate is an important biomolecule and one of the important intermediates in the tricarboxylic acid cycle. It is a transporter of nitrogen and a symbiotic substance in molecular oxidation. It plays an important role in the metabolism of microbial cells and is also an important precursor for the synthesis of a variety of amino acids and proteins.
α-Ketoglutaric acid is a derivative of glutaric acid. It plays an important role in the metabolism of microbial cells and It acts as precursor for the synthesis of amino acids and nucleotides. α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline. α-ketoglutaric acid can be prepared in 1:1 and 2:1 L-arginine alpha-ketoglutarate for sports nutrition. mainly as an ingredient in sports nutrition drinks.
An in vitro study on Alpha-Ketoglutarate demonstrates its ability to up-regulate mRNA expression of genes related to the maintenance of epidermal function.
Only 1% of Alpha-ketoglutarate shows significant of wrinkle/fine line reduction (23.64%) on day 0, immediately after use. It significantly improves the appearance of the nasolabial groove and crow's feet by 15.23% on day 7 and 25.42% on day 56. The skin firmness and radiance also increased significantly, by 41.40% and 28.67%. Alpha-Ketoglutarate Stimulates Procollagen Production and stimulate the hair growth.
Recommended Usage: 0.5-2%
Solubility: Water-soluble
Key Technical Parameters
|
Appearance |
White or off-light yellow crystalline powder |
|
Assay |
≥98% |
|
Transmittance |
≥97% |
|
Iron(Fe) |
≤20ppm |
|
Loss on drying |
≤0.5% |
|
Residue on ignition |
≤0.5% |
|
Heavy metal (Pb) |
≤10 ppm |
|
Arsenic |
≤3 ppm |
|
Melting point |
113℃~117℃ |
|
Purity |
≥98% |
Applications
● Whitening Agent
● Antioxidant effect
● Anti-aging effect
● Anti wrinkle effect
● Anti-inflammatory effect
Advantages
● Antioxidant properties
● Stimulates Procollagen Production
● Resist wrinkles
● Stimulation of Hair Growth
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