5-Hydroxytryptophan

5-Hydroxytryptophan(L-5-HTP) is a premium dietary supplement derived from natural sources, serving as a critical precursor to serotonin (the "mood-regulating neurotransmitter") and melatonin (the "sleep hormone"). It offers gentle, science-backed support for balanced mood and restful sleep.

Product Name: 5-Hydroxytryptophan
Product Code: YNR®L-5-HTP
CAS No.: 4350-09-8
Molecular Formula： C11H12N2O3

Product Detail

product details

product description

5-Hydroxytryptophan(L-5-HTP) is a compound naturally derived from the seeds of the African plant Griffonia simplicifolia. It functions as a direct precursor and biochemical building block for the essential neurotransmitter, Serotonin.

Commonly referred to as the "happiness molecule," Serotonin plays a fundamental role in regulating mood, sleep, and appetite. Supplementation with 5-Hydroxytryptophan supplies the body with the fundamental material required to optimally maintain this crucial biochemical pathway, thereby supporting the body's intrinsic mechanisms for overall well-being.

Main Benefits & Functions
Mood Balance Support: As a direct precursor to serotonin—the neurotransmitter often called the "feel-good chemical"—5-Hydroxytryptophan plays a critical role in maintaining healthy serotonin levels in the brain. Clinical research suggests it may help ease occasional low mood, reduce feelings of stress, and promote emotional resilience by supporting the brain’s natural mood-regulating pathways. Unlike some synthetic mood-support supplements, 5-Hydroxytryptophan works with the body’s physiology to foster balanced emotional states.
Healthy Sleep Promotion: it acts as a precursor to melatonin, the hormone that governs the body’s circadian rhythm. By supporting the conversion of serotonin to melatonin, 5-Hydroxytryptophan helps regulate the sleep-wake cycle, aiding in faster sleep onset and improving overall sleep quality.

Key Technical Parameters

Appearance	White to Off-White Powder
Solubility (10mg/mL)	Clear and transparent, without obvious insolubles.
IR Identification	IR Complies
Particle Size	98% through 80 mesh
Bulk Density	NLT 0.38g/mL
Tapped Density	NLT 0.58g/mL
Loss on Drying	NMT 0.5 %
Residue on Ignition	NMT 0.3 %
pH	4.5 ~ 6.5
Optical Rotation (20°C)	-30.0° ~ -35.0°
Heavy Metals	NMT 10 ppm
Lead (Pb)	NMT 0.5 ppm
Arsenic (As)	NMT 0.5 ppm
Cadmium (Cd)	NMT 0.1 ppm
Mercury (Hg)	NMT 0.1 ppm
Assay	NLT 99.0 %
DBP	NMT 0.3 ppm
Total Impurities	NMT 0.3 %
Peak X	Negative
Biobased Carbon	100%
Total Plate Count (CFU/g)	NMT 1000 CFU/g
Yeast & Mold (CFU/g)	NMT 100 CFU/g
E.Coli	Absent /10 g
Salmonella	Absent /10 g
Staphylococcus	Absent /10 g
Coliform (MPN/g)	NMT 0.92 MPN/g

Mechanism of Action
5-Hydroxytryptophan’s efficacy stems from its unique ability to cross the blood-brain barrier—a protective layer that limits most substances from entering brain tissue—unlike its precursor, tryptophan, which must compete with other amino acids for absorption. Once in the brain, 5-Hydroxytryptophan is quickly converted to serotonin via the enzyme tryptophan hydroxylase, bypassing a common bottleneck in the body’s natural serotonin production.

This serotonin then serves dual roles: supporting mood regulation in the brain’s limbic system and, in the pineal gland, being converted to melatonin to signal the body it’s time to rest. This natural, two-step pathway makes 5-Hydroxytryptophan a versatile tool for addressing both mood and sleep concerns through physiological processes, rather than artificial disruption