Recombinant III Collagen Raw Materials (Mic 32)

Mic 32 is a small molecule bio-fermented Type III collagen obtained through a programmed pyrolysis process, with a molecular weight of 2 kDa, offering superior transdermal absorption. Clinical test have demonstrated its exceptional anti-wrinkle efficacy.

Product Name: Recombinant III Collagen Raw Materials (Mic 32)
INCI Name: Hydrolyzed Sh-Polypeptide-123
Product Code: YNR®Mic 32
CAS No.: 1375784-79-4
Molecular Weight: 2.0kDa
Functions: Moisturizing, Anti-aging,Nourishing,Anti-wrinkle,

Product Detail

product details

product description

Sh-polypeptide-123 is an anti-aging recombinant (recombined protein) human peptide used in skin care that’s created through fermenting a form of yeast called Pichia pastoris (AKA _Komagataella pastoris_). It’s a biomimetic ingredient that resembles the human collagen alpha-1 (III) chain, a crucial component of type 3 collagen, the second most abundant type in skin.

Recombinant human peptides are exciting ingredients touted to support healthy collagen production and tensile strength, resulting in a visible reduction in the appearance of fine lines and wrinkles, a decrease in visible skin laxity, improved skin firmness, smoother skin and improved hydration.

内容插图-Recombinant III Collagen Raw Materials (Mic 32)-1

Chemists use bioengineering practices to extract a “code” for a desired DNA sequence into a vector, a particle that can replicate in a host cell. In the case of sh-polypeptide-123, this is the code for collagen alpha-1 (III). Then, this vector containing code is introduced into a host cell (for sh-polypeptide-123, it’s Pichia pastoris yeast cells) and fermented. These host cells are then purified and prepared for use in cosmetics as well as supplements.

内容插图-Recombinant III Collagen Raw Materials (Mic 32)-2

Sh-Polypeptide-123 is often used in serums, sheet masks, anti-aging creams, concentrated boosters and post-procedure soothing gels where it works alongside humectants and antioxidants to reinforce the skin’s surface.

This peptide is prized for one clear purpose:

Skin protecting: By mimicking segments of native collagen it forms a lightweight, breathable film on the skin that defends against environmental stressors like pollution and dehydration. This shield helps maintain moisture, supports a smoother feel and can reduce the appearance of fine lines over time.

Key Technical Parameters

Appearance	White or off-white powder with very slight odor
Sequence coverage	Peptide sequence coverage 100%
Average molecular mass(D)	≤2000
Solubility（mg/mL）	≥100
pH(1mg/mL )	4.0-8.0
Moisture(%)	≤10.0
Protein content %(on the dried basis)	≥90.0
Pb(mg/kg)	≤10
As(mg/kg)	≤2
Hg(mg/kg)	≤1
Cd(mg/kg)	≤5
Methanol (mg/kg)	≤100
Diethylene glycol (mg/kg)	≤30
Total aerobic count (cfu/g)	≤100
Mold and Yeast (cfu/g)	≤10
Thermotolerant coliform bacteria	Negative
Pseudomonas aeruginosa	Negative
Staphylococcus aureus	Negative