Recombinant III Collagen Raw Materials (SSE)

Sh-Polypeptide-123 is a lab-crafted fragment of human collagen type III used mainly for skin protecting. It forms a lightweight film that shields against pollution and moisture loss, helping skin stay smooth supple and less lined.Its popularity is increasing as brands search for vegan collagen alternatives.

Product Name: Recombinant III Collagen Raw Materials (SSE)
INCI Name: SH-Polypeptide-123
Product Code: YNR®SSE
CAS No.: 1375784-79-4
Molecular Weight: 55.0kDa
Functions: Repair,Anti-aging,Nourishing,Anti-wrinkle,Anti-hair loss

product details

product description

Product Introduction

Sh-Polypeptide-123 is a lab-designed version of a fragment of human collagen type III, produced through fermentation using the yeast Pichia pastoris. Scientists first identified collagen peptides as valuable skin conditioning agents in the early 2000s, and advances in genetic engineering soon allowed them to recreate precise collagen-like chains without relying on animal sources. To make Sh-Polypeptide-123, researchers synthesize a gene that resembles the one our bodies use to build collagen alpha-1(III).

This gene is inserted into Pichia pastoris, which then grows in large stainless-steel tanks, churning out the peptide. After fermentation the peptide is collected, purified and blended into a stable liquid or powder ready for cosmetic use. Because the chain can be up to 1 466 amino acids long it is rich in the same building blocks found in skin, and may include natural crosslinks like disulfide bonds or gentle sugar groups that help it stay flexible and water loving.

You will most often see Sh-Polypeptide-123 in serums, sheet masks, anti-aging creams, concentrated boosters and post-procedure soothing gels where it works alongside humectants and antioxidants to reinforce the skin’s surface.

This peptide is prized for one clear purpose:

Skin protecting: By mimicking segments of native collagen it forms a lightweight, breathable film on the skin that defends against environmental stressors like pollution and dehydration. This shield helps maintain moisture, supports a smoother feel and can reduce the appearance of fine lines over time.

Because this collagen-mimicking peptide is lightweight and non-comedogenic it works for dry, normal, combination and oily skin alike. Its film-forming action helps lock in water without feeling heavy, making it a good option even for sensitive or redness-prone complexions that struggle with fragranced or highly acidic products. The only group that may need caution is anyone with a known allergy to yeast fermentation by-products, though such reactions are rare in finished cosmetics.

The peptide does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection remains important for overall skin health.

Key Technical Parameters

Appearance	White or off-white powder with very slight odor
Formula weight	Retention time similar with standard substance
Absorbance(1% solution , 274nm)	≤0.5
Nitrogen content	≥17%
Purity	≥90%
Loss on drying	≤6.0%
Residue on ignition	≤2.0%
pH(1% solution)	4.0-8.0
Pb	≤2mg/kg
As	≤0.1mg/kg
Hg	≤0.1mg/kg
Cd	≤0.1mg/kg
Methanol	≤100mg/kg
Total aerobic count	≤100 cfu/g
Mold and Yeast	≤10 cfu/g
Thermotolerant coliform bacteria	Negative
Pseudomonas aeruginosa	Negative
Staphylococcus aureus	Negative