Schizophyllan

Schizophyllan, also known as Schizophyllan polysaccharide or Sizofiran, is one of the primary active components of Schizophyllum commune (commonly known as Bai Shen or Tree Flower). It is primarily extracted from this fungus through industrial fermentation technology.Schizophyllan is a β-glucan predominantly composed of glucose. Its main chain consists of β-(1→3)-D-glucan, with a β-(1→6) branch attached to every third glucose residue. This structure forms a rigid rod-like triple helix, conferring high stability and significant biological activity.

Product Name: Schizophyllan
INCI Name: Schizophyllan
Product Code:I YNR®SPG
CAS No.: 9050-67-3
Formula: C24H42O21
Functions: Moisturizer,Anti-inflammatory,Anti-aging ,Sensitive Skin Repair

Product Detail

product details

product description

Schizophyllan is a β-glucan predominantly composed of glucose. Its main chain consists of β-(1→3)-D-glucan, with a β-(1→6) branch attached to every third glucose residue. This structure forms a rigid rod-like triple helix, conferring high stability and significant biological activity.

Schizophyllan is an extracellular polysaccharide produced by the fungus Schizophyllum commune.This fungus is widely found in natural environments (e.g., decaying wood,soil) and can also be industrially cultivated via submerged fermentation.During fermentation,the polysaccharide is synthesized within approximately 5 days.

The extraction process of Schizophyllan involves:Precipitating the fermentation broth with ethanol to obtain crude extracellular polysaccharide;Extracting the mycelia with hot water, followed by ethanol precipitation of the extract to yield crude intracellular polysaccharide;Deproteinization using either the Sevag method or isoelectric point precipitation in combination with the Sevag method;Final purification through activated carbon decolorization, running water dialysis, ethanol reprecipitation, and vacuum drying to obtain the purified polysaccharide.

In cosmetics and skincare products, Schizophyllan functions primarily as a humectant. It has a relatively safe risk profile and can be used with confidence. It generally poses no risk to pregnant women. Schizophyllan is non-comedogenic (does not cause acne), making it an ideal cosmetic ingredient. It possesses anti-inflammatory and immune-boosting properties. It effectively repairs sun-damaged skin, provides moisturizing and anti-wrinkle benefits, promoting a plump and hydrated complexion.

Schizophyllan is suitable for the following 8 skin types: Sensitive skin, Resistant skin, Dry skin, Tight skin, Wrinkled skin, Non-pigmented skin, Pigmented skin, Oily skin.

Schizophyllan activates innate immunity: It is recognized by Dectin-1 and CR3 receptors on macrophages and dendritic cells, stimulating the secretion of immune factors (e.g., IL-12, TNF-α).This accelerates pathogen clearance (e.g., Staphylococcus aureus) and shortens immune response time.

Schizophyllan suppresses excessive inflammation: During late-stage inflammation, it promotes macrophage transition from a pro-inflammatory to a reparative phenotype, upregulates anti-inflammatory factor IL-10, and blocks the NF-κB signaling pathway.This prevents redness, itching, and stinging caused by immune overactivation.

Schizophyllan reinforces the physical barrier: By enhancing keratinocyte proliferation and collagen synthesis, it accelerates wound healing. It also induces human β-defensin-2 (hBD-2) expression, boosting antimicrobial peptide activity to defend against microbial invasion. Schizophyllan maintains a chemical barrier: its triple-helix structure strongly retains water, preserving the stratum corneum’s moisture content, promoting the generation of natural moisturizing factors and alleviating dryness and desquamation.

Schizophyllan’s moisturizing mechanism: the multiple hydroxyl groups form a hydrating film that instantly boosts stratum corneum hydration, while high-molecular-weight schizophyllan (>1,000 kDa) creates a protective film on the skin surface to reduce transepidermal water loss. Schizophyllan provides whitening enhancement:low-molecular-weight schizophyllan (≤10kDa), with its excellent permeability, delivers immediate hydration, whereas high-molecular-weight schizophyllan encapsulates whitening actives such as phenylethyl resorcinol and licorice flavonoids, releasing them gradually through a three-dimensional network to prolong whitening efficacy. Schizophyllan exhibits antioxidant activity: it scavenges OH,DPPH and other free radicals, mitigating UV-induced oxidative damage. Schizophyllan can be used for post-sun repair:it improves sun-induced spots, wrinkles and loss of skin elasticity.

Key Technical Parameters

Appearance	White to grey powder
Odor	Slightly characteristic odor
Solubility (0.5% in water)	Slightly opalescent solution
pH (0.5% in water)	5.0-8.0
Sulfated ash	≤2.0%
Loss on drying	≤10.0%
Heavy Metals	≤10ppm
Arsenic (As)	≤2ppm
Aerobic plate	≤100CFU/g
Yeast & Molds	≤100CFU/g
Escherichia coli presence	Negative
Salmonella presence	Negative
Content (Total sugar)	≥85.0%