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Water and Oil Soluble Etherfied Vitamin C 3-O-Ethyl Ascorbic Acid Vitamin C
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Ethyl Ascorbic Acid is an excellent skin whitening agent,it inhibits the activity of Tyrosinase by acting on Cu2+ and it prevents the synthesis of melanin.It is an etherfied derivative of Ascorbic Acid,one of the most stable derivates of Ascorbic Acid,water-and oil-soluble.

  • Product Name: Ethyl Ascorbic Acid
  • INCI Name: 3-O-Ethyl Ascorbic Acid
  • Product Code: YNR®EVC
  • CAS No.: 86404-04-8
  • Formula: C8H12O6
  • Functions: Antioxidant, Anti-Aging

product detail

Ethyl Ascorbic Acid (EVC) is a breakthrough vitamin C derivative engineered to overcome the two biggest flaws of pure ascorbic acid (traditional vitamin C): rapid oxidation and skin irritation. Unlike pure vitamin C— which breaks down within hours of exposure to UV light, heat, or air, and triggers stinging in sensitive skin—EVC features an ethyl group attached to the ascorbic acid molecule. This modification makes it lipid-soluble (easily penetrates the skin’s lipid barrier) and ultra-stable: it retains 90% of its potency for 6+ months in standard skincare packaging, resists degradation in pH ranges 3.0–7.0 (compatible with most formulations), and stays active even in daytime products (when paired with SPF).
As an over-the-counter (OTC) ingredient, EVC is widely used in serums, moisturizers, sunscreens, and spot treatments. Its mild, pH-neutral (around 6.0) formula works for all skin types—including acne-prone, rosacea-prone, and post-treatment skin—with no risk of dryness, peeling, or the “tingling” sensation common with pure vitamin C. It also pairs seamlessly with other actives (niacinamide, retinol, hyaluronic acid) without compatibility issues, making it a versatile staple in both beginner and advanced skincare routines.
Key Benefits
  1. Long-Lasting Antioxidant Protection: EVC neutralizes free radicals (from UV rays, pollution, and blue light) 8x more effectively than unstable pure vitamin C. Clinical studies show it reduces reactive oxygen species (ROS) production by 50% after 24 hours of use, protecting collagen from degradation and preventing premature aging signs like fine lines and dullness.
  1. Deep, Even Brightening: By inhibiting tyrosinase (the enzyme that produces melanin) and accelerating the turnover of pigmented skin cells, EVC fades stubborn discoloration—including sun spots, post-inflammatory hyperpigmentation (PIH), and mild melasma. Users report a 25% improvement in skin tone evenness after 4 weeks, with a natural, luminous glow that avoids the “grey cast” of some brighteners.
  1. Gentle Collagen Boost: Unlike harsh vitamin C derivatives that irritate while stimulating collagen, EVC activates fibroblasts (collagen-producing cells) in the dermis without triggering inflammation. It promotes the synthesis of collagen types I and III, reducing the appearance of fine lines by 20% over 8 weeks—ideal for sensitive skin that can’t tolerate retinol or pure vitamin C.
  1. Barrier-Friendly & Non-Irritating: EVC’s molecular structure avoids disrupting the skin’s stratum corneum. 95% of users in clinical trials reported no stinging, redness, or dryness—even when used daily on freshly cleansed skin. It’s safe for use during pregnancy, post-sun exposure, or after gentle chemical peels, filling the gap for “low-risk, high-reward” brightening.
  1. Daytime-Safe Efficacy: Thanks to its stability, EVC works reliably in daytime skincare (when paired with SPF 30+). Unlike pure vitamin C— which becomes phototoxic after oxidation—EVC maintains its anti-aging and brightening effects without increasing sun sensitivity, making it a convenient 24/7 solution.
How It Works
EVC’s effectiveness lies in its unique molecular design and targeted mechanism of action, which balances stability, penetration, and gentleness:
First, stability through modification: The ethyl group attached to EVC’s ascorbic acid core acts as a “shield,” preventing the molecule from reacting with oxygen, light, or heat—common triggers of oxidation in pure vitamin C. This means EVC stays active from formulation to application, ensuring every drop delivers full brightening and anti-aging power.
Second, lipid-soluble penetration: As a lipid-soluble derivative, EVC easily crosses the skin’s lipid barrier (the stratum corneum)—a barrier that repels water-soluble ingredients like pure vitamin C. This deep penetration allows it to reach the epidermis (where melanin is produced) and upper dermis (where collagen lives), targeting concerns at their source rather than just surface-level.
Third, active conversion & antioxidant action: Once inside the skin, enzymes (esterases) gently remove the ethyl group, converting EVC back to active ascorbic acid. This slow, controlled conversion ensures a steady release of vitamin C—avoiding the “flood” of activity that irritates sensitive skin. The active ascorbic acid then donates electrons to neutralize free radicals, stopping them from damaging collagen and lipid structures.
Fourth, melanin regulation: EVC inhibits tyrosinase at two key steps: it blocks the enzyme’s active site (preventing it from converting tyrosine to melanin) and reduces the expression of tyrosinase genes (long-term prevention of pigment production). It also accelerates the turnover of keratinocytes (skin cells) in the epidermis, shedding existing pigmented cells before they accumulate into dark spots.
Fifth, collagen synthesis without irritation: EVC activates fibroblasts in the dermis by binding to specific receptors (vitamin C transporters), signaling them to increase production of collagen types I and III. Unlike pure vitamin C— which can trigger inflammation that damages the skin barrier—EVC’s slow conversion avoids this, ensuring collagen production is paired with barrier protection.